Gabapentin’s connection to podiatry is that it can be used to treat chronic regional pain syndrome and restless leg syndrome which is common among patients seen in podiatry clinical practice. It is mainly used to treat epilepsy, but its use in conditions such as restless leg syndrome and other has increased over time due to clinical experience in its use.

Gabapentin is a prescription medication originally developed to treat epilepsy, but it has since become more widely used for managing neuropathic (nerve-related) pain and certain mood disorders. It works by affecting the way nerves send signals to the brain, calming overactive electrical activity. While not chemically related to benzodiazepines or opioids, gabapentin influences neurotransmitters in a way that can help stabilize nerve firing and reduce sensations of pain, burning, or tingling often caused by conditions like diabetic neuropathy, postherpetic neuralgia (nerve pain after shingles), and fibromyalgia.

In clinical practice, gabapentin is valued for its versatility. Beyond its primary role in seizure control and nerve pain relief, it is sometimes prescribed off-label for conditions like anxiety, restless legs syndrome, or migraine prevention. Dosing typically starts low and is gradually increased, since the body needs time to adjust and the drug’s effectiveness depends on steady levels in the bloodstream. Unlike some stronger pain medications, gabapentin does not carry the same high risk of addiction, though misuse and dependence have been reported, especially when combined with other sedatives.

Like most medications, gabapentin comes with potential side effects. Common ones include dizziness, drowsiness, fatigue, and coordination problems, which can make activities like driving more hazardous until the body adapts. Some people also experience swelling in the extremities or mood changes. Serious side effects are less common but may involve severe allergic reactions or suicidal thoughts, which require immediate medical attention. Because gabapentin is processed by the kidneys, people with impaired kidney function usually need adjusted doses. Overall, gabapentin can be very effective when used appropriately under medical supervision, but careful monitoring is important to balance its benefits with its risks.

Most Useful Resources:
Gabapentin (PodiaPaedia)
NEURONTIN Prescribing Information (Pfizer)
Gabapentin (Wikipedia)